| 8:10 PM | Chicago Cubs @ Kansas City Royals | CHC 100% · KC 0% | CHC -165 | 9 | AWY -165 HM 153 | | — | — | ESPN picks |
| 8:15 PM | Baltimore Orioles @ Texas Rangers | BAL 0% · TEX 100% | TEX -140 | 7.5 | AWY 131 HM -140 | | — | — | ESPN picks |
| 8:15 PM | Colorado Rockies @ St. Louis Cardinals | COL 0% · STL 100% | STL -170 | 8.5 | AWY 158 HM -170 | | — | — | ESPN picks |
| 9:40 PM | Houston Astros @ San Diego Padres | HOU 100% · SD 0% | SD -108 | 8.5 | AWY 101 HM -108 | | — | — | ESPN picks |
| 9:40 PM | Los Angeles Dodgers @ Arizona Diamondbacks | LAD 0% · ARI 100% | LAD -180 | 9 | AWY -180 HM 167 | | — | — | ESPN picks |
| 9:45 PM | Tampa Bay Rays @ Seattle Mariners | TB 100% · SEA 0% | SEA -108 | 6.5 | AWY 101 HM -108 | | — | — | ESPN picks |
| 10:15 PM | Detroit Tigers @ San Francisco Giants | DET 0% · SF 100% | DET -142 | 8.5 | AWY -142 HM 132 | | — | — | ESPN picks |
| 3:05 PM | Atlanta Braves @ New York Yankees | | ATL -136 | 7.5 | AWY -136 HM 127 | | — | — | ESPN picks |
| 4:10 PM | Los Angeles Angels @ Miami Marlins | | MIA -156 | 8 | AWY 146 HM -156 | | — | — | ESPN picks |
| 4:10 PM | Athletics @ Boston Red Sox | | BOS -240 | 9 | AWY 222 HM -240 | | — | — | ESPN picks |
| 6:05 PM | Toronto Blue Jays @ Philadelphia Phillies | | PHI -162 | 9.5 | AWY 134 HM -162 | | — | — | ESPN picks |
| 6:40 PM | New York Mets @ Pittsburgh Pirates | | PIT -142 | 8.5 | AWY 118 HM -142 | | — | — | ESPN picks |
| 6:45 PM | Cincinnati Reds @ Washington Nationals | | CIN -149 | 8.5 | AWY -149 HM 123 | | — | — | ESPN picks |
| 7:10 PM | Chicago Cubs @ Kansas City Royals | | CHC -175 | 9.5 | AWY -175 HM 144 | | — | — | ESPN picks |
| 7:10 PM | Minnesota Twins @ Milwaukee Brewers | | MIL -156 | 8 | AWY 129 HM -156 | | — | — | ESPN picks |
| 7:15 PM | Baltimore Orioles @ Texas Rangers | | TEX -150 | 7.5 | AWY 124 HM -150 | | — | — | ESPN picks |
| 7:15 PM | Cleveland Guardians @ Chicago White Sox | | CLE -131 | 8 | AWY -131 HM 109 | | — | — | ESPN picks |
| 7:15 PM | Colorado Rockies @ St. Louis Cardinals | | STL -163 | 8.5 | AWY 135 HM -163 | | — | — | ESPN picks |
| 7:15 PM | Detroit Tigers @ San Francisco Giants | | SF -110 | 8 | AWY -110 HM -110 | | — | — | ESPN picks |
| 7:15 PM | Houston Astros @ San Diego Padres | | SD -126 | 8 | AWY 104 HM -126 | | — | — | ESPN picks |
