| 9:00 PM | Iowa Hawkeyes @ Washington Huskies | IOWA 100% · WASH 0% | WASH -3 | 41.5 | AWY 130 HM -155 | | — | — | ESPN picks |
| 9:00 PM | Washington State Cougars @ Utah State Aggies | WSU 0% · USU 100% | USU -4 | 44.5 | AWY 154 HM -185 | | — | — | ESPN picks |
| 9:00 PM | Wyoming Cowboys @ San José State Spartans | WYO 100% · SJSU 0% | SJSU -4.5 | 42.5 | AWY 160 HM -192 | | — | — | ESPN picks |
| 10:15 PM | Iowa State Cyclones @ BYU Cougars | ISU 0% · BYU 100% | BYU -11.5 | 46.5 | AWY 360 HM -470 | | — | — | ESPN picks |
| 12:00 PM | Indiana Hoosiers @ Nebraska Cornhuskers | | IU -7.5 | 48.5 | AWY -325 HM 260 | | — | — | ESPN picks |
| 12:00 PM | Texas A&M Aggies @ Missouri Tigers | | MIZ -3.5 | 49.5 | AWY 150 HM -180 | | — | — | ESPN picks |
| 12:00 PM | UCF Knights @ Oklahoma State Cowboys | | OKST -10.5 | 53.5 | AWY 350 HM -455 | | — | — | ESPN picks |
| 12:00 PM | North Carolina Tar Heels @ Pittsburgh Panthers | | PITT -3.5 | 47.5 | AWY 154 HM -185 | | — | — | ESPN picks |
| 12:00 PM | Arizona Wildcats @ West Virginia Mountaineers | | ARIZ -3.5 | 60.5 | AWY -175 HM 145 | | — | — | ESPN picks |
| 12:00 PM | Wake Forest Demon Deacons @ NC State Wolfpack | | WAKE -3.5 | 57.5 | AWY -166 HM 140 | | — | — | ESPN picks |
| 12:00 PM | Tulane Green Wave @ Army Black Knights | | ARMY -3.5 | 48.5 | AWY 140 HM -166 | | — | — | ESPN picks |
| 12:00 PM | Sacramento State Hornets @ Bowling Green Falcons | | BGSU -8.5 | 43.5 | AWY 260 HM -325 | | — | — | ESPN picks |
| 12:30 PM | Ball State Cardinals @ Northwestern Wildcats | | NU -35.5 | 53.5 | | | — | — | ESPN picks |
| 12:45 PM | South Carolina Gamecocks @ Florida Gators | | FLA -10.5 | 58.5 | AWY 360 HM -470 | | — | — | ESPN picks |
| 1:00 PM | Old Dominion Monarchs @ App State Mountaineers | | APP -10 | 47.5 | AWY 295 HM -375 | | — | — | ESPN picks |
| 1:00 PM | Rice Owls @ East Carolina Pirates | | ECU -10 | 46.5 | AWY 300 HM -380 | | — | — | ESPN picks |
| 2:00 PM | Miami (OH) RedHawks @ Massachusetts Minutemen | | M-OH -4.5 | 44.5 | AWY -198 HM 164 | | — | — | ESPN picks |
| 3:30 PM | Texas Longhorns @ Oklahoma Sooners | | TEX -7.5 | 39.5 | AWY -310 HM 250 | | — | — | ESPN picks |
| 3:30 PM | Stanford Cardinal @ Notre Dame Fighting Irish | | ND -39.5 | 54.5 | | | — | — | ESPN picks |
| 3:30 PM | Ole Miss Rebels @ Vanderbilt Commodores | | MISS -9.5 | 54.5 | AWY -355 HM 280 | | — | — | ESPN picks |
| 3:30 PM | UCLA Bruins @ Oregon Ducks | | ORE -10.5 | 57.5 | AWY 320 HM -410 | | — | — | ESPN picks |
| 3:30 PM | Houston Cougars @ Kansas State Wildcats | | KSU -2.5 | 54.5 | AWY 114 HM -135 | | — | — | ESPN picks |
| 3:30 PM | Duke Blue Devils @ Georgia Tech Yellow Jackets | | DUKE -6.5 | 44.5 | AWY -245 HM 200 | | — | — | ESPN picks |
| 3:30 PM | Virginia Tech Hokies @ California Golden Bears | | VT -10 | 53.5 | AWY -375 HM 295 | | — | — | ESPN picks |
| 3:30 PM | Illinois Fighting Illini @ Michigan State Spartans | | ILL -2.5 | 48.5 | AWY -135 HM 114 | | — | — | ESPN picks |
| 3:30 PM | Charlotte 49ers @ North Texas Mean Green | | UNT -28.5 | 58.5 | AWY 1700 HM -4500 | | — | — | ESPN picks |
| 3:30 PM | Tulsa Golden Hurricane @ Navy Midshipmen | | NAVY -1.5 | 48.5 | AWY 102 HM -122 | | — | — | ESPN picks |
| 3:30 PM | Eastern Michigan Eagles @ Akron Zips | | EMU -5.5 | 51.5 | AWY -218 HM 180 | | — | — | ESPN picks |
| 3:30 PM | Buffalo Bulls @ Toledo Rockets | | TOL -18.5 | 55.5 | AWY 700 HM -1100 | | — | — | ESPN picks |
| 3:30 PM | Central Michigan Chippewas @ Ohio Bobcats | | OHIO -1.5 | 46.5 | AWY 110 HM -130 | | — | — | ESPN picks |
| 3:30 PM | Kent State Golden Flashes @ Western Michigan Broncos | | WMU -14 | 43.5 | AWY 440 HM -600 | | — | — | ESPN picks |
| 3:45 PM | UConn Huskies @ Temple Owls | | TEM -3.5 | 54.5 | AWY 150 HM -180 | | — | — | ESPN picks |
| 4:15 PM | Maryland Terrapins @ Ohio State Buckeyes | | OSU -33.5 | 56.5 | | | — | — | ESPN picks |
| 4:15 PM | Tennessee Volunteers @ Arkansas Razorbacks | | TENN -13.5 | 51.5 | AWY -550 HM 410 | | — | — | ESPN picks |
| 6:00 PM | San Diego State Aztecs @ Oregon State Beavers | | ORST -16.5 | 52.5 | AWY 525 HM -750 | | — | — | ESPN picks |
| 7:00 PM | LSU Tigers @ Kentucky Wildcats | | LSU -8.5 | 50.5 | AWY -345 HM 275 | | — | — | ESPN picks |
| 7:00 PM | UAB Blazers @ Memphis Tigers | | MEM -14.5 | 53.5 | AWY 455 HM -625 | | — | — | ESPN picks |
| 7:00 PM | Nevada Wolf Pack @ UTEP Miners | | NEV -9.5 | 49.5 | AWY -375 HM 295 | | — | — | ESPN picks |
| 7:00 PM | North Dakota State Bison @ UNLV Rebels | | NDSU -2.5 | 47.5 | AWY -135 HM 114 | | — | — | ESPN picks |
| 7:00 PM | Coastal Carolina Chanticleers @ Marshall Thundering Herd | | MRSH -4 | 58.5 | AWY 154 HM -185 | | — | — | ESPN picks |
| 7:30 PM | Georgia Bulldogs @ Alabama Crimson Tide | | ALA -2.5 | 51.5 | AWY 105 HM -125 | | — | — | ESPN picks |
| 7:30 PM | USC Trojans @ Penn State Nittany Lions | | PSU -1.5 | 54.5 | AWY 102 HM -122 | | — | — | ESPN picks |
| 7:30 PM | Syracuse Orange @ Virginia Cavaliers | | UVA -11.5 | 49.5 | AWY 340 HM -440 | | — | — | ESPN picks |
| 7:30 PM | Air Force Falcons @ Northern Illinois Huskies | | AF -7 | 46.5 | AWY -310 HM 250 | | — | — | ESPN picks |
| 7:30 PM | James Madison Dukes @ Georgia Southern Eagles | | JMU -7.5 | 51.5 | AWY -310 HM 250 | | — | — | ESPN picks |
| 7:30 PM | Louisiana Ragin' Cajuns @ Louisiana Tech Bulldogs | | LT -3 | 48.5 | AWY 130 HM -155 | | — | — | ESPN picks |
