| 8:05 PM | Colorado Rockies @ Chicago Cubs | COL 0% · CHC 100% | CHC -211 | 10 | AWY 172 HM -211 | | — | — | ESPN picks |
| 9:40 PM | Baltimore Orioles @ Seattle Mariners | BAL 100% · SEA 0% | SEA -137 | 7.5 | AWY 114 HM -137 | | — | — | ESPN picks |
| 9:40 PM | Pittsburgh Pirates @ Athletics | PIT 100% · ATH 0% | PIT -143 | 10.5 | AWY -143 HM 119 | | — | — | ESPN picks |
| 1:35 PM | Toronto Blue Jays @ Boston Red Sox | | BOS -126 | 8.5 | AWY 105 HM -126 | | — | — | ESPN picks |
| 2:10 PM | Cleveland Guardians @ Milwaukee Brewers | | MIL -149 | 7.5 | AWY 123 HM -149 | | — | — | ESPN picks |
| 2:35 PM | Minnesota Twins @ Texas Rangers | | MIN -125 | 7.5 | AWY -125 HM 104 | | — | — | ESPN picks |
| 4:10 PM | Baltimore Orioles @ Seattle Mariners | | SEA -157 | 7.5 | AWY 130 HM -157 | | — | — | ESPN picks |
| 6:40 PM | New York Mets @ Philadelphia Phillies | | PHI -126 | 9.5 | AWY 104 HM -126 | | — | — | ESPN picks |
| 7:05 PM | Chicago White Sox @ New York Yankees | | NYY -157 | 9.5 | AWY 130 HM -157 | | — | — | ESPN picks |
| 7:15 PM | San Francisco Giants @ Atlanta Braves | | ATL -143 | 8 | AWY 119 HM -143 | | — | — | ESPN picks |
| 7:40 PM | St. Louis Cardinals @ Kansas City Royals | | KC -120 | 9 | AWY -101 HM -120 | | — | — | ESPN picks |
