| 9:40 PM | Los Angeles Angels @ Athletics | LAA 0% · ATH 100% | ATH -197 | 10 | AWY 161 HM -197 | | — | — | ESPN picks |
| 2:20 PM | Toronto Blue Jays @ Chicago Cubs | | CHC -122 | 7 | AWY 102 HM -122 | | — | — | ESPN picks |
| 6:40 PM | Chicago White Sox @ Detroit Tigers | | DET -237 | 8 | AWY 192 HM -237 | | — | — | ESPN picks |
| 7:05 PM | Cincinnati Reds @ New York Yankees | | NYY -285 | 8.5 | AWY 228 HM -285 | | — | — | ESPN picks |
| 7:10 PM | San Francisco Giants @ Miami Marlins | | | | | | — | — | ESPN picks |
| 7:10 PM | Washington Nationals @ Tampa Bay Rays | | TB -131 | 8 | AWY 108 HM -131 | | — | — | ESPN picks |
| 7:15 PM | Milwaukee Brewers @ Atlanta Braves | | MIL -186 | 7.5 | AWY -186 HM 153 | | — | — | ESPN picks |
