| 8:40 PM | Boston Red Sox @ Colorado Rockies | BOS 0% · COL 100% | BOS -137 | 12 | AWY -137 HM 114 | | — | — | ESPN picks |
| 9:38 PM | Baltimore Orioles @ Los Angeles Angels | BAL 100% · LAA 0% | BAL -158 | 9 | AWY -158 HM 131 | | — | — | ESPN picks |
| 10:00 PM | Atlanta Braves @ San Diego Padres | ATL 0% · SD 100% | SD -117 | 7.5 | AWY -103 HM -117 | | — | — | ESPN picks |
| 4:07 PM | Houston Astros @ Toronto Blue Jays | | TOR -136 | 8.5 | AWY 113 HM -136 | | — | — | ESPN picks |
| 6:40 PM | Kansas City Royals @ Tampa Bay Rays | | TB -193 | 8 | AWY 158 HM -193 | | — | — | ESPN picks |
| 6:40 PM | New York Yankees @ Detroit Tigers | | NYY -118 | 7.5 | AWY -118 HM -102 | | — | — | ESPN picks |
| 6:40 PM | Seattle Mariners @ Pittsburgh Pirates | | SEA -125 | 8 | AWY -125 HM 104 | | — | — | ESPN picks |
| 6:40 PM | Texas Rangers @ Miami Marlins | | MIA -156 | 8.5 | AWY 129 HM -156 | | — | — | ESPN picks |
| 6:45 PM | Philadelphia Phillies @ Washington Nationals | | PHI -167 | 8.5 | AWY -167 HM 138 | | — | — | ESPN picks |
| 7:10 PM | Chicago Cubs @ New York Mets | | NYM -120 | 8.5 | AWY 100 HM -120 | | — | — | ESPN picks |
| 7:10 PM | Milwaukee Brewers @ Cincinnati Reds | | MIL -122 | 10 | AWY -122 HM 101 | | — | — | ESPN picks |
| 7:40 PM | Cleveland Guardians @ Chicago White Sox | | CLE -114 | 7 | AWY -114 HM -105 | | — | — | ESPN picks |
| 7:40 PM | Los Angeles Dodgers @ Minnesota Twins | | LAD -175 | 9 | AWY -175 HM 144 | | — | — | ESPN picks |
| 7:45 PM | Arizona Diamondbacks @ St. Louis Cardinals | | STL -114 | 8.5 | AWY -105 HM -114 | | — | — | ESPN picks |
