| 6:10 PM | New York Yankees @ Detroit Tigers | | NYY -131 | 8.5 | AWY -131 HM 108 | | — | — | ESPN picks |
| 6:40 PM | Kansas City Royals @ Tampa Bay Rays | | TB -193 | 7.5 | AWY 158 HM -193 | | — | — | ESPN picks |
| 6:40 PM | Texas Rangers @ Miami Marlins | | MIA -126 | 8.5 | AWY 105 HM -126 | | — | — | ESPN picks |
| 6:45 PM | Philadelphia Phillies @ Washington Nationals | | WSH -115 | 10 | AWY -105 HM -115 | | — | — | ESPN picks |
| 7:07 PM | Houston Astros @ Toronto Blue Jays | | TOR -123 | 7.5 | AWY 102 HM -123 | | — | — | ESPN picks |
| 7:10 PM | Chicago Cubs @ New York Mets | | CHC -120 | 8.5 | AWY -120 HM -101 | | — | — | ESPN picks |
| 7:10 PM | Milwaukee Brewers @ Cincinnati Reds | | MIL -168 | 9.5 | AWY -168 HM 139 | | — | — | ESPN picks |
| 7:40 PM | Cleveland Guardians @ Chicago White Sox | | CLE -114 | 7.5 | AWY -114 HM -105 | | — | — | ESPN picks |
| 7:40 PM | Los Angeles Dodgers @ Minnesota Twins | | LAD -157 | 9.5 | AWY -157 HM 130 | | — | — | ESPN picks |
| 7:45 PM | Arizona Diamondbacks @ St. Louis Cardinals | | STL -144 | 8.5 | AWY 119 HM -144 | | — | — | ESPN picks |
