| 8:05 PM | Washington Nationals @ Texas Rangers | WSH 100% · TEX 0% | TEX -116 | 7.5 | AWY 108 HM -116 | | — | — | ESPN picks |
| 8:10 PM | Los Angeles Angels @ Houston Astros | LAA 0% · HOU 100% | HOU -147 | 8.5 | AWY 137 HM -147 | | — | — | ESPN picks |
| 8:40 PM | Los Angeles Dodgers @ Colorado Rockies | LAD 100% · COL 0% | LAD -193 | 11.5 | AWY -193 HM 179 | | — | — | ESPN picks |
| 12:40 PM | St. Louis Cardinals @ Cincinnati Reds | | STL -112 | 9 | AWY -112 HM 104 | | — | — | ESPN picks |
| 1:10 PM | San Francisco Giants @ Cleveland Guardians | | CLE -180 | 7.5 | AWY 167 HM -180 | | — | — | ESPN picks |
| 1:10 PM | Toronto Blue Jays @ Tampa Bay Rays | | TB -160 | 7.5 | AWY 149 HM -160 | | — | — | ESPN picks |
| 2:10 PM | Athletics @ Kansas City Royals | | KC -136 | 8.5 | AWY 126 HM -136 | | — | — | ESPN picks |
| 2:10 PM | Seattle Mariners @ Milwaukee Brewers | | MIL -121 | 8 | AWY 112 HM -121 | | — | — | ESPN picks |
| 2:10 PM | Atlanta Braves @ Chicago White Sox | | ATL -106 | 8.5 | AWY -106 HM -101 | | — | — | ESPN picks |
| 6:35 PM | New York Yankees @ Baltimore Orioles | | NYY -131 | 8 | AWY -131 HM 109 | | — | — | ESPN picks |
