| 8:05 PM | Chicago White Sox @ Chicago Cubs | CHW 0% · CHC 100% | CHC -170 | 9.5 | AWY 158 HM -170 | | — | — | ESPN picks |
| 8:05 PM | Washington Nationals @ Texas Rangers | WSH 0% · TEX 100% | TEX -136 | 7.5 | AWY 127 HM -136 | | — | — | ESPN picks |
| 8:10 PM | Los Angeles Angels @ Houston Astros | LAA 100% · HOU 0% | HOU -163 | 9 | AWY 152 HM -163 | | — | — | ESPN picks |
| 8:40 PM | Los Angeles Dodgers @ Colorado Rockies | LAD 100% · COL 0% | LAD -193 | 11.5 | AWY -193 HM 179 | | — | — | ESPN picks |
| 12:35 PM | Detroit Tigers @ Pittsburgh Pirates | | PIT -153 | 8 | AWY 142 HM -153 | | — | — | ESPN picks |
| 1:10 PM | San Diego Padres @ New York Mets | | SD -128 | 8.5 | AWY -128 HM 119 | | — | — | ESPN picks |
| 1:40 PM | Atlanta Braves @ Minnesota Twins | | ATL -108 | 8.5 | AWY -108 HM 101 | | — | — | ESPN picks |
| 2:20 PM | Chicago White Sox @ Chicago Cubs | | CHC -140 | 8 | AWY 130 HM -140 | | — | — | ESPN picks |
| 4:10 PM | Arizona Diamondbacks @ Boston Red Sox | | BOS -140 | 8 | AWY 131 HM -140 | | — | — | ESPN picks |
| 6:05 PM | Miami Marlins @ Philadelphia Phillies | | PHI -130 | 8.5 | AWY 108 HM -130 | | — | — | ESPN picks |
| 6:35 PM | New York Yankees @ Baltimore Orioles | | NYY -121 | 9 | AWY -121 HM 101 | | — | — | ESPN picks |
| 6:40 PM | San Francisco Giants @ Cleveland Guardians | | CLE -186 | 7 | AWY 153 HM -186 | | — | — | ESPN picks |
| 6:40 PM | St. Louis Cardinals @ Cincinnati Reds | | CIN -149 | 8.5 | AWY 123 HM -149 | | — | — | ESPN picks |
| 6:40 PM | Toronto Blue Jays @ Tampa Bay Rays | | TB -217 | 7.5 | AWY 177 HM -217 | | — | — | ESPN picks |
| 7:40 PM | Athletics @ Kansas City Royals | | KC -136 | 8.5 | AWY 113 HM -136 | | — | — | ESPN picks |
| 7:40 PM | Seattle Mariners @ Milwaukee Brewers | | MIL -125 | 7 | AWY 104 HM -125 | | — | — | ESPN picks |
