| 8:10 PM | Athletics @ Houston Astros | ATH 0% · HOU 100% | HOU -176 | 8.5 | AWY 163 HM -176 | | — | — | ESPN picks |
| 8:10 PM | Detroit Tigers @ Kansas City Royals | DET 0% · KC 100% | DET -105 | 8 | AWY -105 HM -103 | | — | — | ESPN picks |
| 8:15 PM | Los Angeles Angels @ Texas Rangers | LAA 0% · TEX 100% | TEX -136 | 7.5 | AWY 127 HM -136 | | — | — | ESPN picks |
| 8:40 PM | Cleveland Guardians @ Colorado Rockies | CLE 100% · COL 0% | CLE -150 | 10.5 | AWY -150 HM 140 | | — | — | ESPN picks |
| 9:40 PM | Cincinnati Reds @ Arizona Diamondbacks | CIN 0% · ARI 100% | ARI -151 | 8.5 | AWY 141 HM -151 | | — | — | ESPN picks |
| 9:40 PM | Minnesota Twins @ San Diego Padres | MIN 0% · SD 100% | SD -119 | 8 | AWY 111 HM -119 | | — | — | ESPN picks |
| 10:10 PM | Chicago Cubs @ Seattle Mariners | CHC 0% · SEA 100% | SEA -105 | 7.5 | AWY -103 HM -105 | | — | — | ESPN picks |
| 10:10 PM | Pittsburgh Pirates @ Los Angeles Dodgers | PIT 0% · LAD 100% | LAD -229 | 8 | AWY 212 HM -229 | | — | — | ESPN picks |
| 1:35 PM | Toronto Blue Jays @ New York Yankees | | NYY -108 | 7 | AWY 101 HM -108 | | — | — | ESPN picks |
| 2:10 PM | Atlanta Braves @ Milwaukee Brewers | | MIL -165 | 8 | AWY 153 HM -165 | | — | — | ESPN picks |
| 4:10 PM | Washington Nationals @ Miami Marlins | | MIA -175 | 7.5 | AWY 163 HM -175 | | — | — | ESPN picks |
| 6:05 PM | St. Louis Cardinals @ Philadelphia Phillies | | PHI -136 | 9 | AWY 113 HM -136 | | — | — | ESPN picks |
| 7:05 PM | Tampa Bay Rays @ Baltimore Orioles | | TB -132 | 8 | AWY -132 HM 110 | | — | — | ESPN picks |
| 7:05 PM | Los Angeles Angels @ Texas Rangers | | TEX -175 | 8 | AWY 144 HM -175 | | — | — | ESPN picks |
| 7:10 PM | Athletics @ Houston Astros | | HOU -245 | 8 | AWY 198 HM -245 | | — | — | ESPN picks |
| 7:10 PM | New York Mets @ Chicago White Sox | | CHW -117 | 8 | AWY -103 HM -117 | | — | — | ESPN picks |
| 7:15 PM | San Francisco Giants @ Boston Red Sox | | BOS -217 | 8 | AWY 177 HM -217 | | — | — | ESPN picks |
| 7:15 PM | Detroit Tigers @ Kansas City Royals | | KC -110 | 8.5 | AWY -110 HM -110 | | — | — | ESPN picks |
| 7:15 PM | Chicago Cubs @ Seattle Mariners | | SEA -120 | 8 | AWY 100 HM -120 | | — | — | ESPN picks |
| 7:15 PM | Pittsburgh Pirates @ Los Angeles Dodgers | | LAD -267 | 7.5 | AWY 214 HM -267 | | — | — | ESPN picks |
