| 8:10 PM | Cleveland Guardians @ Colorado Rockies | CLE 100% · COL 0% | CLE -129 | 11 | AWY -129 HM 120 | | — | — | ESPN picks |
| 8:10 PM | Cincinnati Reds @ Arizona Diamondbacks | CIN 100% · ARI 0% | ARI -187 | 8.5 | AWY 173 HM -187 | | — | — | ESPN picks |
| 8:40 PM | Minnesota Twins @ San Diego Padres | MIN 0% · SD 100% | SD -139 | 8 | AWY 129 HM -139 | | — | — | ESPN picks |
| 1:35 PM | St. Louis Cardinals @ Philadelphia Phillies | | PHI -210 | 7.5 | AWY 195 HM -210 | | — | — | ESPN picks |
| 1:35 PM | Tampa Bay Rays @ Baltimore Orioles | | TB -108 | 8.5 | AWY -108 HM 101 | | — | — | ESPN picks |
| 1:35 PM | Toronto Blue Jays @ New York Yankees | | NYY -129 | 7.5 | AWY 120 HM -129 | | — | — | ESPN picks |
| 1:40 PM | Washington Nationals @ Miami Marlins | | MIA -157 | 8.5 | AWY 146 HM -157 | | — | — | ESPN picks |
| 2:10 PM | Athletics @ Houston Astros | | HOU -176 | 9 | AWY 163 HM -176 | | — | — | ESPN picks |
| 2:10 PM | Detroit Tigers @ Kansas City Royals | | DET -106 | 8.5 | AWY -106 HM -102 | | — | — | ESPN picks |
| 2:10 PM | New York Mets @ Chicago White Sox | | NYM -108 | 8 | AWY -108 HM 101 | | — | — | ESPN picks |
| 2:35 PM | Los Angeles Angels @ Texas Rangers | | TEX -154 | 8 | AWY 143 HM -154 | | — | — | ESPN picks |
| 3:10 PM | Cleveland Guardians @ Colorado Rockies | | CLE -165 | 11 | AWY -165 HM 153 | | — | — | ESPN picks |
| 3:15 PM | San Francisco Giants @ Boston Red Sox | | BOS -217 | 8 | AWY 201 HM -217 | | — | — | ESPN picks |
| 4:10 PM | Chicago Cubs @ Seattle Mariners | | CHC -105 | 7.5 | AWY -105 HM -102 | | — | — | ESPN picks |
| 4:10 PM | Minnesota Twins @ San Diego Padres | | SD -136 | 8.5 | AWY 126 HM -136 | | — | — | ESPN picks |
| 4:10 PM | Pittsburgh Pirates @ Los Angeles Dodgers | | LAD -272 | 8.5 | AWY 250 HM -272 | | — | — | ESPN picks |
| 4:15 PM | Cincinnati Reds @ Arizona Diamondbacks | | ARI -127 | 8.5 | AWY 119 HM -127 | | — | — | ESPN picks |
| 7:00 PM | Atlanta Braves @ Milwaukee Brewers | | MIL -130 | 7.5 | AWY 108 HM -130 | | — | — | ESPN picks |
