| 8:05 PM | San Diego Padres @ Texas Rangers | SD 0% · TEX 100% | TEX -157 | 7 | AWY 130 HM -157 | | — | — | ESPN picks |
| 8:10 PM | Cleveland Guardians @ Houston Astros | CLE 0% · HOU 100% | HOU -125 | 8.5 | AWY 104 HM -125 | | — | — | ESPN picks |
| 8:15 PM | St. Louis Cardinals @ Kansas City Royals | STL 0% · KC 100% | STL -120 | 9 | AWY -120 HM 100 | | — | — | ESPN picks |
| 8:40 PM | Pittsburgh Pirates @ Colorado Rockies | PIT 0% · COL 100% | PIT -143 | 11.5 | AWY -143 HM 119 | | — | — | ESPN picks |
| 9:40 PM | Los Angeles Angels @ Athletics | LAA 0% · ATH 100% | ATH -157 | 10 | AWY 130 HM -157 | | — | — | ESPN picks |
| 9:45 PM | Minnesota Twins @ Arizona Diamondbacks | MIN 0% · ARI 100% | ARI -175 | 8.5 | AWY 144 HM -175 | | — | — | ESPN picks |
| 10:10 PM | Baltimore Orioles @ Los Angeles Dodgers | BAL 0% · LAD 100% | LAD -224 | 9 | AWY 182 HM -224 | | — | — | ESPN picks |
| 10:10 PM | Boston Red Sox @ Seattle Mariners | BOS 100% · SEA 0% | SEA -117 | 6.5 | AWY -103 HM -117 | | — | — | ESPN picks |
| 1:10 PM | Chicago White Sox @ Detroit Tigers | | DET -143 | 8.5 | AWY 119 HM -143 | | — | — | ESPN picks |
| 1:35 PM | Cincinnati Reds @ New York Yankees | | NYY -199 | 9.5 | AWY 163 HM -199 | | — | — | ESPN picks |
| 2:20 PM | Toronto Blue Jays @ Chicago Cubs | | CHC -131 | 9 | AWY 108 HM -131 | | — | — | ESPN picks |
| 4:05 PM | San Diego Padres @ Texas Rangers | | TEX -136 | 7.5 | AWY 113 HM -136 | | — | — | ESPN picks |
| 4:10 PM | Milwaukee Brewers @ Atlanta Braves | | ATL -131 | 7 | AWY 109 HM -131 | | — | — | ESPN picks |
| 4:10 PM | San Francisco Giants @ Miami Marlins | | MIA -143 | 8 | AWY 119 HM -143 | | — | — | ESPN picks |
| 4:10 PM | Washington Nationals @ Tampa Bay Rays | | TB -122 | 8.5 | AWY 102 HM -122 | | — | — | ESPN picks |
| 7:15 PM | Cleveland Guardians @ Houston Astros | | HOU -143 | 8.5 | AWY 119 HM -143 | | — | — | ESPN picks |
| 7:15 PM | New York Mets @ Philadelphia Phillies | | PHI -185 | 7.5 | AWY 152 HM -185 | | — | — | ESPN picks |
