| 9:10 PM | Pittsburgh Pirates @ Colorado Rockies | PIT 0% · COL 100% | PIT -225 | 10.5 | AWY -225 HM 183 | | — | — | ESPN picks |
| 10:05 PM | Los Angeles Angels @ Athletics | LAA 100% · ATH 0% | ATH -162 | 10 | AWY 134 HM -162 | | — | — | ESPN picks |
| 10:10 PM | Boston Red Sox @ Seattle Mariners | BOS 100% · SEA 0% | SEA -126 | 7 | AWY 105 HM -126 | | — | — | ESPN picks |
| 10:10 PM | Baltimore Orioles @ Los Angeles Dodgers | BAL 100% · LAD 0% | LAD -288 | 8 | AWY 230 HM -288 | | — | — | ESPN picks |
| 10:10 PM | Minnesota Twins @ Arizona Diamondbacks | MIN 100% · ARI 0% | ARI -120 | 9.5 | AWY 100 HM -120 | | — | — | ESPN picks |
| 1:35 PM | Cincinnati Reds @ New York Yankees | | NYY -118 | 8.5 | AWY -102 HM -118 | | — | — | ESPN picks |
| 1:35 PM | Milwaukee Brewers @ Atlanta Braves | | ATL -131 | 8.5 | AWY 108 HM -131 | | — | — | ESPN picks |
| 1:40 PM | Chicago White Sox @ Detroit Tigers | | DET -120 | 8 | AWY -101 HM -120 | | — | — | ESPN picks |
| 1:40 PM | San Francisco Giants @ Miami Marlins | | SF -148 | 8 | AWY -148 HM 123 | | — | — | ESPN picks |
| 1:40 PM | Washington Nationals @ Tampa Bay Rays | | TB -136 | 8 | AWY 113 HM -136 | | — | — | ESPN picks |
| 2:10 PM | Cleveland Guardians @ Houston Astros | | HOU -136 | 8.5 | AWY 113 HM -136 | | — | — | ESPN picks |
| 2:10 PM | St. Louis Cardinals @ Kansas City Royals | | STL -125 | 9 | AWY -125 HM 104 | | — | — | ESPN picks |
| 2:20 PM | Toronto Blue Jays @ Chicago Cubs | | TOR -122 | 6.5 | AWY -122 HM 101 | | — | — | ESPN picks |
| 2:35 PM | San Diego Padres @ Texas Rangers | | TEX -149 | 7.5 | AWY 123 HM -149 | | — | — | ESPN picks |
| 3:10 PM | Pittsburgh Pirates @ Colorado Rockies | | PIT -149 | 12 | AWY -149 HM 123 | | — | — | ESPN picks |
| 3:15 PM | Minnesota Twins @ Arizona Diamondbacks | | | | | | — | — | ESPN picks |
| 4:05 PM | Los Angeles Angels @ Athletics | | ATH -126 | 9 | AWY 104 HM -126 | | — | — | ESPN picks |
| 4:10 PM | Baltimore Orioles @ Los Angeles Dodgers | | LAD -219 | 9 | AWY 178 HM -219 | | — | — | ESPN picks |
| 4:10 PM | Boston Red Sox @ Seattle Mariners | | SEA -143 | 6.5 | AWY 119 HM -143 | | — | — | ESPN picks |
| 7:20 PM | New York Mets @ Philadelphia Phillies | | PHI -207 | 8 | AWY 169 HM -207 | | — | — | ESPN picks |
