| 8:05 PM | Chicago White Sox @ Chicago Cubs | CHW 0% · CHC 100% | CHC -155 | 8 | AWY 145 HM -155 | | — | — | ESPN picks |
| 8:40 PM | Los Angeles Dodgers @ Colorado Rockies | LAD 100% · COL 0% | LAD -283 | 11 | AWY -283 HM 260 | | — | — | ESPN picks |
| 6:35 PM | New York Yankees @ Baltimore Orioles | | NYY -118 | 8.5 | AWY -118 HM -102 | | — | — | ESPN picks |
| 6:40 PM | Detroit Tigers @ Pittsburgh Pirates | | PIT -149 | 8 | AWY 123 HM -149 | | — | — | ESPN picks |
| 6:40 PM | Miami Marlins @ Philadelphia Phillies | | PHI -254 | 8 | AWY 205 HM -254 | | — | — | ESPN picks |
| 6:40 PM | San Francisco Giants @ Cleveland Guardians | | CLE -193 | 8 | AWY 158 HM -193 | | — | — | ESPN picks |
| 6:40 PM | St. Louis Cardinals @ Cincinnati Reds | | STL -123 | 8.5 | AWY -123 HM 102 | | — | — | ESPN picks |
| 6:40 PM | Toronto Blue Jays @ Tampa Bay Rays | | TB -144 | 7.5 | AWY 119 HM -144 | | — | — | ESPN picks |
| 7:10 PM | Arizona Diamondbacks @ Boston Red Sox | | BOS -171 | 8.5 | AWY 141 HM -171 | | — | — | ESPN picks |
| 7:10 PM | San Diego Padres @ New York Mets | | SD -118 | 8.5 | AWY -118 HM -102 | | — | — | ESPN picks |
| 7:40 PM | Athletics @ Kansas City Royals | | KC -143 | 9.5 | AWY 119 HM -143 | | — | — | ESPN picks |
| 7:40 PM | Seattle Mariners @ Milwaukee Brewers | | MIL -162 | 7.5 | AWY 134 HM -162 | | — | — | ESPN picks |
| 7:40 PM | Atlanta Braves @ Minnesota Twins | | ATL -131 | 8.5 | AWY -131 HM 109 | | — | — | ESPN picks |
